![]() NONMEM Users Guide: Introduction to NONMEM 7 Example: Fortran 77: IF(ICALL.EQ.3) THEN WRITE(50,*) CL,V ENDIF Fortran 95: IF(ICALL=3) THEN WRITE(50,*) CL,V ENDIF The list of operators are Name of logical operator Equal to Not equal to Greater than Greater than or equal to Less than Less than or equal to Fortran 77. In addition, Fortran 95 allows you to use these alternative symbols for logical operators: ![]() Whereas formerly, a variable in a common block may have been referenced using verbatim code as: COMMON/PROCM2/DOSTIM,DDOST(30),D2DOST(30,30) Now, you would reference a variable as follows: USE PROCM_REAL,ONLY: DOSTIM And you can reference only that variable that you need, without being concerned with order. I.3 Expansions on Abbreviated and Verbatim Code The greatest changes are the renaming of many of the internal variables, and their repackaging from COMMON blocks to Modules. All REAL variables are now DOUBLE PRECISION (15 significant digits). Furthermore, machine constants are evaluated by intrinsic functions in Fortran, which allows greater portability between platforms. The IMSL routines have also been updated to Fortran 90/95. I.2 Modernized Code All code has been modernized from Fortran 77 to Fortran 90/95. 39: The section Stable Model Development was added. 32: The shrinkage equation for using an alternative number of etas was corrected 3) P. 27, 28 The table List of $EST Settings and Their Relevance to Various Methods has been modified. Changes to this document from Intro7: Minor changes to this document are the following 1) p. The additional files are as follows: root.ext v i r root.phi Where root is the root name (not including extension) of the control stream file given at the NONMEM command line, or root=nmbayes if the control stream file name is not given at the NONMEM command line. Attention: NONMEM 7 produces a series of additional output files which may interfere with files specified by the user in legacy control stream files. ![]() The choice of estimation methods has been expanded to include Monte Carlo expectation and Monte Carlo Bayesian methods, greater control of performance for the classical NONMEM methods such as FOCE and Laplace, and additional post-analysis diagnostic statistics. In addition to code modification and centralization of common variables for easier access and revision, the program has been expanded to allow a larger range of inputs for data items, initial parameter settings, and formatting of outputs. NONMEM Users Guide: Introduction to NONMEM 7 I.1 Introduction Many changes and enhancements have been made from NONMEM VI release 2.0 to NONMEM 7. Bauer ICON Development Solutions Ellicott City, Maryland February 26, 2010 NONMEM USERS GUIDE INTRODUCTION TO NONMEM 7 Version 7.1.2 Robert J. ![]()
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